Humanism and the Renaissance at the end of the 15th century were currents that exalted knowledge and reason above the superstition of the Middle Ages. These Humanist principles directly influenced settings such as the Cathedral and Doncel de Sigüenza, the Universities of Alcalá de Henares and Salamanca or the Palacio del Pardo, where these currents arrived loaded with new ideas, coming mainly from Italy. We see all these scenarios with a new perspective thanks to a 3D Scanner.